"The Pollinic Girls Attack!" is a manga series that blends elements of science fiction, action, and comedy. The narrative centers around a group of genetically engineered girls known as the Pollinic Girls, who are created to combat a mysterious alien threat. These girls possess unique abilities tied to pollination, which they use to protect Earth from extraterrestrial invaders. The story unfolds in a near-future setting where humanity faces an existential crisis due to the alien menace.

The protagonist, Aya, is the leader of the Pollinic Girls and exhibits exceptional combat skills and strategic thinking. Her abilities are linked to wind-based pollination, allowing her to manipulate air currents and create powerful attacks. The other members of the team include Hana, whose powers are rooted in floral pollination, enabling her to generate plant-based weapons and healing abilities; Yuki, who specializes in frost pollination, capable of freezing enemies and creating ice barriers; and Rin, whose insect-based pollination allows her to summon swarms of insects for reconnaissance and combat.

The plot begins with the sudden appearance of alien creatures that disrupt Earth's ecosystems and threaten human survival. The Pollinic Girls are deployed as humanity's last line of defense, tasked with neutralizing the alien threat while uncovering its origins. As the story progresses, the girls face increasingly formidable foes, each with unique abilities that challenge their teamwork and individual strengths. The narrative explores their personal struggles, including the ethical implications of their creation and the burden of being humanity's protectors.

A recurring antagonist, an enigmatic alien commander, serves as the primary adversary. This character orchestrates the invasions and possesses a deep understanding of the Pollinic Girls' abilities, often exploiting their weaknesses. The conflict escalates as the girls discover a hidden connection between their creation and the alien threat, leading to revelations about their purpose and the true nature of the invaders.

The series balances intense action sequences with moments of camaraderie and humor, highlighting the girls' distinct personalities and their growth as a team. Themes of identity, sacrifice, and the consequences of genetic engineering are woven into the narrative, adding depth to the overarching plot. The manga concludes with a climactic battle that resolves the immediate alien threat while leaving room for potential future developments.