"Kono Hentai Yarō!" centers on the life of Shōta Katori, a high school student with a peculiar and often misunderstood personality. Shōta is labeled as a pervert by his peers due to his eccentric behavior and unconventional interests, which frequently lead to awkward and comedic situations. Despite his reputation, Shōta is not malicious; his actions stem from a genuine curiosity and a lack of social awareness rather than ill intent.

The narrative explores Shōta's daily interactions with his classmates, particularly focusing on his relationship with Aoi Sakuraba, a diligent and serious classmate who often finds herself entangled in Shōta's antics. Aoi initially views Shōta with disdain but gradually begins to understand his quirks, leading to a dynamic that oscillates between frustration and reluctant camaraderie. Other key characters include Shōta's childhood friend, Yūka Tachibana, who is more accepting of his eccentricities, and the class president, Rina Fujisaki, who often mediates conflicts arising from Shōta's behavior.

The plot unfolds through a series of episodic chapters, each highlighting Shōta's misadventures and the reactions of those around him. These scenarios often involve misunderstandings, slapstick humor, and moments of unexpected sincerity. While the series leans heavily into comedy, it occasionally delves into themes of acceptance, individuality, and the challenges of navigating social norms. The characters' growth is subtle but evident, particularly in how they learn to coexist with Shōta's unique personality.

The manga balances humor with occasional heartfelt moments, creating a narrative that is both entertaining and reflective of the complexities of human relationships. The interactions between Shōta and his peers drive the story forward, offering a mix of lighthearted comedy and character-driven development. The series does not shy away from portraying the awkwardness and misunderstandings that arise from Shōta's behavior, but it also emphasizes the importance of empathy and understanding in overcoming social barriers.