"Hataraki Mono" centers on Hiroko Matsukata, a 28-year-old editor working at Jidai, a weekly magazine in Tokyo. The narrative explores her professional and personal life, highlighting the challenges of balancing demanding work responsibilities with societal expectations for women in contemporary Japan. Hiroko is dedicated to her job, often working long hours and navigating tight deadlines, office politics, and the pressures of producing quality content. Her commitment to her career sometimes clashes with her personal relationships, particularly with her boyfriend, Hiroshi, who struggles to understand her workaholic tendencies.

The series delves into the dynamics of Hiroko's workplace, showcasing her interactions with colleagues, including her supportive boss, Tanaka, and her competitive coworker, Izumi. Hiroko's determination and resourcefulness are frequently tested as she tackles various editorial challenges, from managing difficult writers to resolving last-minute crises. The manga also examines the broader cultural context of gender roles in the workplace, portraying Hiroko's efforts to assert herself in a male-dominated industry while grappling with societal pressures to conform to traditional expectations.

Throughout the story, Hiroko's character is developed through her professional achievements and personal struggles. Her relationship with Hiroshi evolves as they navigate the complexities of their differing priorities, with Hiroko often prioritizing her career over their time together. The narrative also touches on themes of self-identity, ambition, and the pursuit of fulfillment, as Hiroko reflects on her choices and the sacrifices she makes to succeed in her field.

The manga provides a realistic portrayal of the modern workplace, emphasizing the dedication and resilience required to thrive in a competitive environment. Hiroko's journey is marked by moments of triumph and frustration, offering a nuanced depiction of the challenges faced by working women in Japan. The series balances its focus on Hiroko's professional life with glimpses into her personal world, creating a well-rounded exploration of her character and the societal forces that shape her experiences.