"10-nen Hikikomori! Onna Sannin" centers on three women who have withdrawn from society, each grappling with their own reasons for becoming hikikomori. The narrative explores their shared living arrangement and the challenges they face as they attempt to reintegrate into the outside world. The protagonist, Yuki, is a former office worker who retreated into isolation after a traumatic workplace incident. Her roommate, Maki, is a former idol who left the entertainment industry due to intense public scrutiny and personal struggles. The third member, Rika, is a university dropout who became a recluse after failing to meet familial and societal expectations.

The story unfolds as the three women navigate their daily lives within the confines of their shared apartment, relying on each other for emotional support. Their interactions are marked by moments of humor, tension, and vulnerability, as they confront their fears and insecurities. The narrative delves into their individual backstories, revealing the events that led to their withdrawal and the psychological toll of prolonged isolation.

As the series progresses, the women begin to take small steps toward reconnecting with the outside world. Yuki starts by venturing out to a convenience store, Maki reconnects with a former colleague, and Rika attempts to mend her relationship with her family. These efforts are met with varying degrees of success and setbacks, highlighting the complexities of overcoming social withdrawal. The story emphasizes the importance of mutual support and gradual progress, portraying the characters’ journeys as a series of incremental victories rather than sudden transformations.

Themes of mental health, societal pressure, and the stigma surrounding hikikomori are central to the narrative. The series provides a nuanced portrayal of the challenges faced by individuals who feel alienated from society, offering a compassionate perspective on their struggles. Through its exploration of the characters’ lives, "10-nen Hikikomori! Onna Sannin" sheds light on the realities of social withdrawal and the resilience required to rebuild one’s life.