"Shiritsu Junkan Gakuen" is a manga series set in a fictional high school where students are divided into factions based on their blood types, each with distinct traits and societal roles. The story explores the dynamics and conflicts between these factions, highlighting the rigid social hierarchy and prejudices that arise from this blood type-based system. The protagonist, a transfer student, becomes entangled in the school's complex power struggles, challenging the status quo and uncovering deeper truths about the institution and its origins.

The narrative delves into themes of discrimination, identity, and rebellion, as the protagonist navigates the school's oppressive environment. Key characters include members of each blood type faction, each representing different societal stereotypes and ideologies. The interactions between these characters drive the plot, revealing the systemic injustices and personal struggles within the school. As the protagonist forms alliances and confronts adversaries, the story builds toward a climactic confrontation that questions the validity of the blood type hierarchy and its impact on individual freedom and equality. The series combines elements of drama, action, and social commentary, creating a thought-provoking exploration of societal norms and human behavior.