"Tsukihime" is a manga series adapted from the visual novel of the same name, written by Kinoko Nasu and illustrated by Sasaki Shounen. The story centers on Shiki Tohno, a young man who, after a near-fatal accident in his childhood, gains the ability to see "lines of death" on all living things. By cutting these lines, he can destroy anything, a power he struggles to control and understand. Following the accident, Shiki is sent away from the Tohno family due to his unstable mental state and returns years later to live with his sister, Akiha, after their father's death.

Upon returning to his hometown, Shiki encounters a mysterious girl named Arcueid Brunestud, who claims to be a vampire princess. Arcueid reveals that Shiki's ability is tied to a deeper supernatural world, one filled with vampires, demons, and other entities. Shiki becomes entangled in a conflict involving the True Ancestors, a race of pure vampires, and the Dead Apostles, their corrupted counterparts. Arcueid, a True Ancestor, seeks to eliminate Roa, a Dead Apostle who has reincarnated multiple times and is now targeting Shiki due to his unique abilities.

As the story progresses, Shiki learns more about his own past and the Tohno family's dark secrets. His sister, Akiha, is revealed to possess supernatural abilities tied to the family's lineage, and their relationship becomes strained as Shiki delves deeper into the supernatural world. Other key characters include Ciel, a vampire hunter and former victim of Roa, who aids Shiki in his battles, and Hisui and Kohaku, maids serving the Tohno household, each with their own tragic backstories tied to the family's history.

The narrative explores themes of identity, mortality, and the consequences of wielding power. Shiki's journey is marked by his struggle to reconcile his humanity with his deadly abilities, as well as his relationships with the women around him, each of whom represents a different facet of his life and the supernatural world. The story is divided into multiple arcs, each focusing on different characters and their connections to the overarching conflict, culminating in a confrontation with Roa and the resolution of Shiki's personal struggles.

The manga adaptation remains faithful to the visual novel's intricate plot and character development, offering a detailed exploration of its supernatural elements and emotional depth. It balances action, mystery, and drama, providing a comprehensive look into the world of "Tsukihime" and its complex cast of characters.