"I've Never H!" is a romantic comedy manga that explores themes of self-discovery, relationships, and societal expectations through the lens of its protagonist, a young woman navigating her late twenties. The story centers on Hana, a 28-year-old office worker who has never been in a romantic or sexual relationship. Her lack of experience becomes a source of insecurity, especially as she compares herself to her peers, who seem to effortlessly navigate love and intimacy. Hana's journey begins when she meets Riku, a confident and flirtatious coworker who becomes intrigued by her innocence and straightforward personality.

The narrative delves into Hana's internal struggles as she grapples with societal pressures and her own desires. Riku, who initially appears as a carefree playboy, gradually reveals a more thoughtful and supportive side, encouraging Hana to embrace her individuality rather than conform to societal norms. Their evolving relationship forms the core of the story, blending humor with moments of vulnerability as they navigate misunderstandings, personal growth, and the complexities of modern romance.

Secondary characters, such as Hana's close friend Yumi and Riku's childhood friend Kaito, provide additional layers to the narrative. Yumi serves as a confidante and voice of reason, offering Hana advice and perspective, while Kaito's presence introduces tension and rivalry, complicating the dynamics between Hana and Riku. The manga balances lighthearted comedic moments with introspective scenes, creating a well-rounded exploration of love, self-acceptance, and the challenges of forming meaningful connections in a fast-paced, judgmental world.