"Che Guevara: A Manga Biography" is a biographical manga that chronicles the life of Ernesto "Che" Guevara, the Argentine Marxist revolutionary, from his early years to his death. The narrative begins with Guevara's childhood in Argentina, highlighting his struggles with asthma and his early exposure to leftist ideologies through his family. The story then follows his formative travels across Latin America, particularly the transformative motorcycle journey with his friend Alberto Granado, which exposed him to the widespread poverty and social injustices faced by the region's people.

The manga delves into Guevara's political awakening, detailing his involvement in the Guatemalan Revolution under President Jacobo Árbenz and his subsequent flight to Mexico after the coup. It is in Mexico where Guevara meets Fidel Castro, marking the beginning of his pivotal role in the Cuban Revolution. The narrative meticulously portrays his contributions as a guerrilla leader, strategist, and symbol of resistance, culminating in the overthrow of Cuban dictator Fulgencio Batista.

Post-revolution, the manga explores Guevara's roles in the new Cuban government, including his efforts in land reform, industrialization, and his tenure as Minister of Industry. It also touches on his internationalist endeavors, such as his mission to the Congo and his final campaign in Bolivia, where he aimed to incite a continent-wide revolution. The story concludes with his capture and execution by Bolivian forces, solidifying his legacy as a global icon of rebellion and social justice.

The main characters include Che Guevara himself, depicted as a complex figure driven by idealism and a relentless pursuit of justice. Fidel Castro is portrayed as a charismatic and pragmatic leader, whose partnership with Guevara was instrumental in the Cuban Revolution. Other notable figures include Alberto Granado, whose friendship and shared journey with Guevara provided a foundation for his revolutionary fervor, and various historical figures who played significant roles in Guevara's life and the broader revolutionary movements of the 20th century. The manga presents these characters with a focus on their historical significance and their interactions within the context of Guevara's life and the socio-political landscape of the time.