Laetitia Isambert-Denis is a Canadian actress based in Quebec, whose professional work encompasses both voice acting for animated productions and roles in live-action film and television. Her career is primarily documented through her contributions to the French dubbing of international series and films for the Quebecois market, as well as appearances in local television programs and movies.

Isambert-Denis's voice acting work is closely associated with the Quebecois dubbing industry. A significant and commonly cited role is providing the French voice for the character Princess Sparkle in the animated series Spider Riders. In this series, she voices the young, cheerful, and determined princess of the underground kingdom of Arachna, who is also the youngest member of the titular Spider Riders team. Her voice work extends to other animated projects, including the children's series The ZhuZhus, known in French as Frankie et les ZhuZhus, and the preschool stop-motion series Poko. In Poko, she is credited with voicing the character Bibi. Additional animation credits include providing voices for series such as Luna, Chip & Inkie: Adventure Rangers Go and various films in the Buddies franchise, like Space Buddies and Santa Buddies.

Beyond animation, Isambert-Denis has built a career as a screen actress in Quebecois cinema and television. Her film credits include roles in dramas such as Boris sans Béatrice (2016), where she played the character Justine Malinovsky, and Sans elle (2006), in which she portrayed Malou. More recently, she appeared in the 2023 film Le Successeur, taking on the role of Janie. On television, her credits span several Quebecois series, including roles in the teen drama Tactik and its sequels, the series Nous, and the drama Nouvelle adresse.