Xesca Guillén is a Spanish actress and voice artist, primarily known for her work in dubbing foreign productions into Spanish. She is identified as a Valencian actress. Her professional dubbing career has been active since at least 1989, and she is noted for having a very deep voice.

Guillén's voice acting work includes contributions to anime series. She is credited with providing the Spanish voice for the character Ran Ookubo in the anime series Igano Kabamaru. Ran Ookubo is the headmistress of Kin'gyoku Academy and the grandmother of the character Mai Ookumo in the series.

Beyond anime, her dubbing career encompasses a wide range of live-action films and television series. Her credits include providing the Spanish voice for actors in productions such as the film Mushi-shi, the television series Mad About You, and the miniseries Coco Chanel.

In addition to dubbing, Guillén has performed voice-over narration for original projects. She narrated the character of Margarita in the short film Margarita, a role that held personal significance for her as the story was inspired by a poem her own grandmother used to read to her.