Seth Rogen has established a distinct and prolific career as a voice actor in animated features, often bringing his recognizable comedic persona to a wide array of characters. His entry into voice acting began in 2007 with a minor role as a ship captain in Shrek the Third. That same year, he was cast as Mantis, one of the Furious Five, in the DreamWorks Animation film Kung Fu Panda, a role he would reprise in multiple sequels and specials over the following years. This marked the beginning of a long association with major animation studios.

A defining characteristic of Rogen's voice work is his approach to character creation, where he typically uses his natural speaking voice rather than adopting a distinct vocal performance. This was a conscious condition he set for one of his most high-profile roles, Donkey Kong in The Super Mario Bros. Movie. He was clear with the filmmakers that his involvement meant the character would sound like him, a request they accepted. Rogen reasoned that the character's established traits from the video games, primarily his adversarial relationship with Mario, provided enough comedic material without needing an exaggerated voice. This philosophy is a consistent thread throughout his filmography, from his early work as Morton the Mouse in Horton Hears a Who! to the gelatinous monster B.O.B. in Monsters vs. Aliens.

His voice acting credits encompass a diverse range of projects, spanning family-friendly entertainment and adult-oriented animation. He voiced the beloved warthog Pumbaa in the 2019 photorealistic remake of The Lion King, performing alongside Billy Eichner as Timon. In a sharp contrast to that family-friendly fare, he also co-wrote, produced, and voiced the lead role of Frank in the R-rated animated comedy Sausage Party. His production company, Point Grey Pictures, has been heavily involved in animation, notably for the 2023 film Teenage Mutant Ninja Turtles: Mutant Mayhem. For this project, Rogen, who also voiced the character Bebop, championed a recording process that brought actors together in the same booth to capture improvisational energy, a method he appreciated from his experience on The Lion King.

His contributions to animation have become a significant part of his broader career, which also includes live-action acting, writing, directing, and producing. In 2023 alone, his voice was featured in two major animated releases, The Super Mario Bros. Movie and Teenage Mutant Ninja Turtles: Mutant Mayhem, highlighting his prominence in the field. The following year, he continued voicing Mantis in Kung Fu Panda 4 and appeared in Mufasa: The Lion King. Rogen's animated filmography shows a pattern of recurring collaborations, with frequent returns to the Kung Fu Panda franchise and partnerships with actors like James Franco and filmmakers such as the team behind The Super Mario Bros. Movie, solidifying his status as a sought-after and consistent presence in animated voice work.