Joe Manganiello is an American actor who has occasionally worked as a voice actor for animated projects, including several with themes and styles that appeal to anime audiences. His most prominent association with the anime world is through the live-action adaptation of the popular anime and manga series One Piece.

While the user mentions Mr. 0 in the series One Piece: Into the Grand Line as an example, this is a live-action role and not an anime voice acting role. Mr. 0 is the alias of the villain Sir Crocodile, and Manganiello portrays this character in the Netflix live-action adaptation of One Piece. In interviews, he has noted that he tips his cap to the performance of the Japanese voice actor from the original anime, indicating his respect for the source material and its voice acting legacy.

Manganiello's actual work as a voice actor includes a role in the animated anthology series Love, Death & Robots. In the third season, he provided the voice for the character Coulthard in an episode. He also voiced the character Mongrel in the 2021 adult animated dark fantasy film The Spine of Night. Earlier in his career, he lent his voice to the character Hefty Smurf in the 2017 computer-animated film Smurfs: The Lost Village.

His work in the realm of animation also includes voice roles in several television series. He voiced the character Ax Tagrin in two episodes of Star Wars Resistance and has appeared as the voice of Viper Fang in the animated series Big City Greens. He also voiced a character named Mike Donkey in an episode of American Dad!.

Additionally, Manganiello was announced as a cast member for the anime series Army of the Dead: Lost Vegas, a Netflix anime spinoff prequel to Zack Snyder's film Army of the Dead. In this series, he was set to voice a character named Rose.