Information on Chris Simms as an anime voice actor is limited, but a confirmed credit establishes his presence in the industry. He is primarily known for providing the voice for the character Angel, who also transforms into Devil Dog, in the English language dub of the surreal horror anime series Gregory Horror Show. This series, which aired from 1999 to 2006, features a unique cast of characters in a purgatorial hotel, and Simms's role as the dual natured Angel and Devil Dog is one of the notable performances in the English adaptation.

Beyond this prominent role, voice acting credits are listed under the names Chris Simms and Kris Simms. As Chris Simms, his work includes the role of Dejiko in Di Gi Charat Nyo, Mog in Fancy Lala, and Marie Louise in Mobile Fighter G Gundam. Under the alias Kris Simms, he is credited as the voice of Puar in the Blue Water dub of the classic series Dragon Ball. A small number of video game voice roles are also associated with him, including Kadie in Crimson Tears and Pallette in Mega Man X8. The overall record of his career, including any recurring collaborations with specific directors or studios, remains sparse.