"Panty-Monium" centers on a chaotic and surreal world where the boundaries between reality and absurdity blur. The narrative revolves around a young man named Hiroshi, an ordinary office worker who stumbles upon a mysterious pair of sentient panties with supernatural abilities. These panties, named Panty and Stocking, possess distinct personalities: Panty is brash, confident, and hedonistic, while Stocking is more reserved, gothic, and sardonic. Together, they form an unlikely duo tasked with protecting the city from malevolent spirits and grotesque monsters that emerge from the underworld.

The story unfolds in a series of episodic adventures, each featuring bizarre and often comedic encounters with various supernatural entities. Panty and Stocking wield their unique powers—Panty transforms her panties into a gun, while Stocking uses her stockings as swords—to combat these threats. Their missions are often fueled by personal desires, such as Panty’s relentless pursuit of romantic encounters or Stocking’s craving for sweets, which adds a layer of irreverent humor to the narrative.

Supporting characters include Garterbelt, a flamboyant and enigmatic priest who serves as the duo’s mentor and provides them with missions, and Brief, a timid and socially awkward boy who becomes infatuated with Panty. The series also introduces antagonists like Scanty and Kneesocks, demonic sisters who mirror Panty and Stocking in appearance and abilities but serve the forces of evil. Their clashes with the protagonists escalate the stakes, leading to increasingly chaotic and over-the-top battles.

The plot takes unexpected turns, blending slapstick comedy, dark humor, and surreal visuals. The episodic structure allows for a variety of tones, ranging from lighthearted and absurd to dark and satirical. As the series progresses, the line between good and evil becomes increasingly ambiguous, culminating in a climactic confrontation that challenges the protagonists’ motivations and the nature of their existence. The narrative’s unpredictability and eccentricity make it a distinctive entry in the anime genre, appealing to audiences who enjoy unconventional storytelling and bold, irreverent humor.