Isuke Natsumura is a Japanese voice actor known for their work in adult animation and video games. The name Isuke Natsumura is an alias used by the voice actor Keisuke Nakamura for performances in adult-oriented content. Their career in voice acting spans from at least 2009 to 2022.

A significant portion of Natsumura's credited roles are in original video animation series. The Anime News Encyclopedia confirms their participation in a number of such productions. These roles include Kanzaki in the series Vampire Vixen, Kurosawa in Fuzzy Lips, Yuujin in Love Bitch, Furuu in The Wife is Micael, the Referee in The Lewd Boat, Akasaka in DISCIPLINE Zero, and Tamura in Maneaters Gang: Last Order.

Additional voice credits further illustrate the scope of their work. In the 2014 series Furueru Kuchibiru, they provided the voice for Kurosawa, and in the same year, they voiced Kanzaki in Vampire Vixen. Other notable performances from this period include roles in Chichi-iro Toiki, Sex Code of the Samurai, and the Toshi Densetsu Series. Earlier in their career, they voiced Sugiyama Shuuichi in the 2009 series Fault!!. In the Shoujo Ramune television miniseries, which aired from 2016 to 2018, they were the voice of Kiyoshi Tachikawa. Their work extends into video games as well; Natsumura Isuke voiced the protagonist Kuma in the 2021 visual novel Dohna Dohna.