"DISCIPLINE Zero" is an adult-oriented anime series set in a private high school, St. Lancaster Academy, which serves as the primary backdrop for the story. The narrative centers on Takashiro Kazuya, a new transfer student who becomes entangled in a web of romantic and sexual entanglements with several female students and faculty members. The series explores themes of power dynamics, manipulation, and desire within the confines of the school environment.

Kazuya's arrival at St. Lancaster Academy quickly draws the attention of multiple women, including the student council president, Aoi Kazuki, who exerts significant influence over the school. Aoi is portrayed as a dominant and calculating figure, often using her authority to manipulate others. Another key character is Ruriko Nishina, a teacher who becomes romantically involved with Kazuya, further complicating his relationships within the school. The interactions between Kazuya and these women are marked by a mix of coercion, seduction, and emotional conflict, highlighting the series' focus on adult themes.

The plot unfolds through a series of interconnected episodes, each delving into Kazuya's evolving relationships with the women around him. The narrative frequently shifts perspectives, providing insight into the motivations and vulnerabilities of the female characters. Despite the overtly sexual nature of many interactions, the series occasionally touches on deeper emotional struggles, such as loneliness, insecurity, and the desire for genuine connection.

As the story progresses, Kazuya finds himself increasingly caught between the competing desires and agendas of the women in his life. The power dynamics within the school create a tense atmosphere, with alliances and rivalries constantly shifting. The series concludes with an open-ended resolution, leaving the ultimate fate of Kazuya and his relationships ambiguous.

"DISCIPLINE Zero" is characterized by its explicit content and mature themes, making it suitable only for adult audiences. The series does not shy away from depicting the complexities of its characters' relationships, though it often prioritizes sensationalism over nuanced storytelling. The narrative structure and character dynamics are central to the series, offering a blend of drama, romance, and eroticism within the confines of a high school setting.