"Manga Hajimete Monogatari" is a slice-of-life anime that centers on the experiences of a young girl named Chitose Kobayashi, who aspires to become a manga artist. Set in post-World War II Japan, the series explores her journey as she navigates the challenges of pursuing her dream in a society still recovering from the war's aftermath. Chitose's passion for manga is fueled by her admiration for Osamu Tezuka, a pioneering figure in the manga industry, whose works inspire her to create her own stories.

The narrative follows Chitose as she moves to Tokyo to live with her aunt and uncle, leaving behind her rural hometown. In Tokyo, she encounters a vibrant but competitive world of manga creation, where she faces both personal and professional obstacles. Chitose's determination is tested as she deals with self-doubt, societal expectations, and the demanding nature of the manga industry. Along the way, she forms friendships with other aspiring artists, including her classmate Miyako, who shares her passion for manga, and her supportive but strict mentor, a seasoned manga editor.

The series delves into the creative process of manga-making, highlighting the dedication and perseverance required to succeed in the field. It also portrays the cultural and historical context of 1950s Japan, emphasizing the role of manga as a form of escapism and expression during a time of societal rebuilding. Through Chitose's experiences, the anime explores themes of ambition, resilience, and the pursuit of one's dreams, offering a heartfelt depiction of the challenges and triumphs of a young artist. The characters are grounded and relatable, with their struggles and growth reflecting the broader human experience.