"Ometeotl≠HERO" is a science fiction anime series set in a dystopian future where humanity faces extinction due to a catastrophic event known as the "Great Collapse." The story unfolds in a world where advanced technology and ancient mythology intertwine, creating a unique narrative framework. The central premise revolves around the emergence of powerful beings called "Deities," who possess god-like abilities and are believed to be the key to humanity's survival. These Deities are manifestations of ancient Aztec gods, each representing different aspects of nature and human emotion.

The protagonist, Kaito Tachibana, is a young man who becomes entangled in the conflict surrounding the Deities after encountering one named Quetzalcoatl. Quetzalcoatl, a serpent-like Deity, bonds with Kaito, granting him extraordinary powers but also burdening him with the responsibility of protecting humanity. Kaito's journey is marked by his struggle to understand his new role and the moral dilemmas that arise from wielding such immense power. Alongside Kaito is a diverse group of characters, including Aya Fujisaki, a determined scientist researching the Deities, and Ryota Hayama, a former soldier seeking redemption for past failures.

The plot is driven by the escalating conflict between factions vying for control over the Deities. The "Ometeotl Organization," a secretive group, seeks to harness the Deities' power to restore balance to the world, while the "Neo-Tenochtitlan Empire" aims to exploit them for domination. As Kaito and his allies navigate this treacherous landscape, they uncover the truth behind the Great Collapse and the origins of the Deities, revealing a deeper connection between humanity and these ancient entities.

The narrative explores themes of sacrifice, identity, and the consequences of wielding power, as the characters grapple with their roles in a world on the brink of destruction. The series balances intense action sequences with moments of introspection, creating a compelling story that delves into the complexities of human nature and the enduring legacy of myth. Through its intricate plot and well-developed characters, "Ometeotl≠HERO" offers a thought-provoking exploration of a future where the line between gods and humans becomes increasingly blurred.