"Pico×CoCo×Chico" is a short-form anime series that revolves around the daily lives of three anthropomorphic animal characters: Pico, a penguin; CoCo, a rabbit; and Chico, a chick. The narrative is episodic, focusing on their humorous and lighthearted interactions as they navigate everyday situations. Each episode is brief, typically lasting only a few minutes, and emphasizes comedic timing and slapstick humor.

The trio lives together in a shared house, and their personalities drive much of the humor. Pico is often portrayed as the laid-back and somewhat lazy member of the group, while CoCo is energetic and occasionally mischievous. Chico, the youngest, is curious and naive, often serving as the catalyst for comedic misunderstandings. The series does not follow a continuous plot but instead presents standalone scenarios, such as preparing meals, playing games, or dealing with minor household mishaps. These situations are exaggerated for comedic effect, with the characters frequently engaging in over-the-top reactions and physical comedy.

The humor in "Pico×CoCo×Chico" is largely visual and relies on the characters' expressive animations and exaggerated movements. Dialogue is minimal, making the series accessible to a wide audience regardless of language barriers. The interactions between the trio often highlight their contrasting personalities, creating a dynamic that is both entertaining and endearing. Despite the lack of a overarching storyline, the series maintains a consistent tone of lighthearted fun, making it suitable for viewers seeking quick, comedic entertainment.