"Oni no Hanayome wa Taberaretai" is a fantasy romance anime that centers on the relationship between a human and an oni, blending elements of supernatural lore with comedic and romantic undertones. The protagonist, a young man named Kaito, finds himself in an unusual predicament when he is chosen as the bride of an oni princess named Yuki. In this world, oni are powerful, demon-like beings who traditionally consume humans to sustain their strength. However, Yuki, despite being an oni, harbors a deep affection for Kaito and struggles with her instinctual desire to devour him.

The narrative explores the tension between Yuki's love for Kaito and her inherent nature as an oni. Kaito, initially terrified of being eaten, gradually develops feelings for Yuki as he witnesses her efforts to suppress her predatory instincts. Their relationship is further complicated by the societal expectations of the oni world, where consuming humans is seen as a rite of passage and a symbol of power. Yuki's refusal to harm Kaito places her at odds with her own kind, leading to conflicts with other oni who view her actions as a betrayal of their traditions.

Supporting characters include other oni who challenge or support Yuki's choices, as well as humans who become entangled in the supernatural dynamics. The story delves into themes of love, identity, and the struggle to reconcile one's nature with personal desires. The interplay between humor and tension creates a dynamic narrative, as Yuki's comedic attempts to resist her urges contrast with the genuine danger she poses to Kaito. The series balances lighthearted moments with emotional depth, examining the complexities of a relationship that defies societal norms and biological imperatives.