"Fujiko Fujio no Kiteretsu Daihyakka" is a science-fiction comedy anime series centered around Kiteretsu, a young genius inventor, and his adventures in the fictional town of Kiteretsu City. Kiteretsu, a bright and resourceful boy, creates a wide array of fantastical inventions in his laboratory, often using them to solve problems or help others. His creations range from practical gadgets to whimsical contraptions, reflecting his boundless curiosity and ingenuity.

Kiteretsu's best friend is Korosuke, a mischievous and gluttonous robot who often accompanies him on his escapades. Despite his tendency to cause trouble, Korosuke is fiercely loyal and provides comic relief throughout the series. The duo frequently interacts with other recurring characters, such as Miyoko, a kind-hearted and studious girl who is Kiteretsu's classmate and close friend, and Tongari, a boastful and competitive boy who often challenges Kiteretsu but secretly admires his talents.

The series is episodic, with each episode typically featuring a new invention or problem that Kiteretsu must address. These scenarios often involve everyday challenges, such as helping a friend, overcoming a personal obstacle, or outsmarting a rival. However, the inventions and situations frequently take on a fantastical or exaggerated tone, blending humor with lighthearted moral lessons. For example, Kiteretsu might create a time machine to fix a mistake or build a device to help Miyoko win a competition, only for the invention to malfunction in unexpected ways.

A recurring antagonist is the greedy and bumbling Mr. Kite, who often schemes to steal Kiteretsu's inventions for his own gain. Despite his persistent efforts, Mr. Kite's plans are invariably foiled by Kiteretsu's cleverness and the unintended consequences of his own actions. This dynamic adds a layer of conflict and humor to the series, as Kiteretsu and Korosuke must repeatedly outwit Mr. Kite and his henchmen.

The narrative emphasizes themes of friendship, creativity, and problem-solving, with Kiteretsu's inventions serving as a metaphor for the power of imagination and perseverance. The series balances its comedic elements with moments of warmth and sincerity, creating a tone that is both entertaining and uplifting. Through its episodic structure and relatable characters, "Fujiko Fujio no Kiteretsu Daihyakka" offers a charming exploration of curiosity and ingenuity in a world where science and imagination intersect.