Manami Mitama is a main character in A Centaur's Life. She is the eldest of five sisters, with three triplet sisters named Chigusa, Chinami, and Chiho, and a younger sister named Suetsumi. Manami’s family runs a shrine, and she works part-time as a shrine maiden. She is half-angel by birth, her mother being an angel and her father a cat-man, which gives her a halo that is actually a hair decoration intended to reflect angelic culture rather than a magical item. Manami has very long white hair and blue eyes, and she is depicted with wings.

Within the story, Manami serves as the class representative for her class, which includes the centaur Himeno Kimihara and the demon Nozomi Gokuraku. She is also a member of the student council. Her role is that of a responsible and conscientious student who takes her duties seriously. Her personality is strict and hardworking, and she holds herself to high standards. She is deeply caring toward her family members, especially her maternal grandfather, who entrusted the entire family to her care before his passing. This sense of duty drives her motivation to be a dependable older sister and a capable student leader.

Manami’s relationships with her younger sisters are central to her character; she is protective and nurturing, displaying a strong big-sister instinct. Her bond with the younger and sickly Suetsumi is particularly emphasized. Among her classmates, she is respected but can come across as stern due to her rigorous sense of responsibility. Her development is subtle, centered on balancing her familial obligations with her school life and personal identity, though her core traits remain consistent. Notable abilities include her organizational skills as class monitor and her part-time duties at the shrine, alongside the cultural significance of her angelic features.