In the second season of Space Dandy, the titular character remains a boisterous and unflappable alien hunter, though the narrative deepens the mystery surrounding his very existence. As the captain of the spaceship Aloha Oe, Dandy continues his largely unsuccessful quest to discover undocumented alien species for the Alien Registration Center. He is a man driven by simple, immediate pleasures, chiefly his obsession with the breastaurant chain Boobies and a pronounced fascination with the female posterior. Despite often appearing lazy, self-centered, and prone to misunderstanding almost any situation, he consistently demonstrates an underlying charisma and a surprising capacity for compassion toward the unusual life forms he encounters.

A significant development in the second season is the expansion of Dandy's cosmic significance. While outwardly he is a poor marksman and a mediocre bounty hunter whose pride is regularly wounded by the Registration Center's inspector Scarlet, the series reveals that he is a unique and pivotal figure in the universe. It is discovered that Dandy's body contains no trace of DNA, instead registering immense amounts of Pyonium, an extremely rare particle. This energy is linked to the revelation that Dandy is an anomaly capable of willingly traversing multiple dimensions and parallel universes. This explains the show's frequent lack of continuity and reset-button scenarios; each episode might be a different universe, yet Dandy remains a constant, singular presence. His complete obliviousness to this profound power is a core aspect of his personality, as he remains far more focused on his immediate whims.

His key relationships continue to define his adventures. He is accompanied by Meow, a Betelgeusian cat-like alien who is often lazy and glued to social media, and QT, a pragmatic and sentient vacuum cleaner-shaped robot who frequently points out the crew's ineptitude. His dynamic with Scarlet evolves beyond simple frustration, with episodes in the second season hinting at a poignant, unexplored romantic tension where both characters fail to bridge an emotional gap despite a clear mutual affection. His primary antagonist, the Gogol Empire, continues to pursue him, believing he holds the key to controlling the universe, though Dandy is largely unaware of their efforts. His favorite waitress at Boobies, Honey, remains the emblem of his unattainable desires. His personal development is subtle but impactful; season two forces him into situations that test his hedonistic philosophy. Notably, in the series finale, after gaining the attention of a god-like narrator, Dandy is offered the position of God of a new universe. He refuses the offer not out of humility or principle, but because accepting would mean losing his physical body, a sacrifice he deems unacceptable as it would make visiting Boobies boring. This choice perfectly encapsulates his character: the boundless potential of the cosmos is secondary to his loyalty to base pleasures.

In terms of abilities, Dandy is a deeply unreliable combatant. His gunplay is notoriously inaccurate, often failing to hit clustered targets. However, he possesses exceptional talent in other areas. He is a highly skilled pilot, particularly in the Aloha Oe's mecha pod, the Little Aloha, where his recklessness becomes a tactical advantage. He is also an expert surfer, capable of navigating treacherous debris fields. The second season confirms his most significant, albeit passive, ability: his role as a dimensional anchor, allowing him to be the same individual across multiple realities, a secret power that he himself does not understand or intentionally wield.