Lise Harriette Meyer is a student at a private school in New York City and a close friend of Kate Ashley, as well as of the other three main girls: Rachel, Rose, and Claire. She is described as a gentle and beautiful young woman with a kind heart, known among her friends for being open and honest. Her suspicious death early in the story serves as the catalyst for the entire series. She is found dead in a forest, and the police investigate the circumstances. The four girls, who had gone looking for her after she disappeared, later discover that they themselves died the same night and were reanimated by the organization Animus. Lise was also meant to be reanimated, but monsters prevented that from happening. It is revealed that she died after meeting a young man with whom she had become smitten, a secret she kept even from her close friends, which seems uncharacteristic for her normally forthright nature. Throughout the series, her friends seek her reanimated body while grappling with their own new existence and the supernatural conflict between the Animus and Dolore clans. Lise does not appear as a living or reanimated character in the main events; her role is that of an absent figure whose memory and unresolved fate drive the emotional and narrative stakes for the four protagonists. Her background includes coming from a wealthy family, and she is remembered as a beloved friend whose loss deeply affects Kate in particular. She has no notable combat or supernatural abilities, as she never becomes an active participant in the battles. Her character is defined by the mystery surrounding her death and the loyalty she inspires in her friends.