In the anime series Street Fighter II V, Cammy appears as a character distinct from her more common video game portrayal. Her background in this adaptation is that of a highly skilled contract assassin, formerly a special forces operative. She is hired by the villainous boxer Balrog to carry out a mission of assassination.

Cammy's role in the story is directly tied to this assignment. She is dispatched to eliminate the father of Chun-Li, a key character in the series. Her attempt is ultimately thwarted by the martial arts action star Fei Long, who intervenes and stops her. Following this confrontation, Cammy comes to the realization that Balrog had deceived her and manipulated her into the act. In response, she turns on her employer and nearly kills him.

Her physical appearance in Street Fighter II V is unique to this series and a significant departure from her iconic look. She does not have the scar on her cheek that is present in the games. Her long blonde hair is styled in a single high ponytail instead of the familiar double braids. Her attire consists of form-fitting black leather pants, a matching black leather tank top, red gloves, red boots, and a black choker necklace that holds a silver cross. This cross is notable as it conceals a deadly garrote, which she uses as her primary assassination tool.

In terms of personality, this version of Cammy is portrayed as a capable and dangerous operative, a driven young woman who is fearless in combat and uses her extensive skills to fulfill her objectives. While she carries a tough and professional demeanor, her motivations are not purely villainous, as her actions following the revelation of Balrog's trickery show a capacity for independent judgment. Her role in the overall narrative, however, is limited, and she largely disappears from the plot after her initial conflict is resolved. Her primary ability in this series is her proficiency in assassination techniques, making use of her agility and the concealed wire weapon to deadly effect.