Zakusa Ishigame, the son of a potter, studies Japanese art at college, where his artistic perspective shapes unique expressions that often elude others' comprehension. He fights as a member of Team Blackout using a Brandt Gate deck focused on the Cardinal ride line. This deck deploys "World" Set Orders to create conditions such as "Dark Night" and "Abyssal Dark Night," activating normal unit effects while generating Shadow Army Tokens as its core strategy.

During will+Dress Season 1, serving as second-in-command to team leader Yu-yu Kondo, he discreetly monitors Yu-yu and others after significant losses, fostering team cohesion. His deck evolves during this time, integrating the new ace unit Cardinal Dominus, Orfist Regis to enhance his strategy.

Recruited by the antagonistic Uniformers under the alias "Shirogane," he rebuilds his deck, securing multiple victories against strong fighters, including an off-screen win against Taizo Kiyokura. His most notable confrontation occurs against Yu-yu Kondo in will+Dress episode 34, where he emerges victorious, displaying heightened capabilities under the Uniformers.

He later battles Megumi Okura in the Divinez DELUXE arc, with the outcome remaining unknown. His journey reflects shifting loyalties, tactical evolution, and personal transformation, culminating in his role as a strategically adaptive cardfighter.