Big Billy features as a Gangreen Gang member in the anime adaptation, renamed "Big Boy" in the English dub. He stands as the gang's largest and strongest member, wielding significant physical strength frequently used in their criminal endeavors. His notably robust physique is paired with a consistent appetite, depicted as a source of increased power for him. This version differs from his original series counterpart by not being a cyclops and wearing a white shirt instead of green. During a direct challenge to Powered Buttercup in episode 14, specifically a vehicle-lifting contest, he demonstrates his strength by lifting a car. Powered Buttercup surpasses this feat by lifting a much larger bus, defeating him. This outcome visibly frightens him, underscoring the considerable power gap between his strength and hers.