Megu Kataoka fights the Demon King Koro-sensei as a student in Class 3-E within the RPG-inspired world of *Koro Sensei Quest!*. Her core personality and leadership traits remain consistent with her *Assassination Classroom* portrayal, adapted to the spin-off's comedic tone. She frequently acts as class representative alongside Yuma Isogai, displaying responsibility. Her athleticism and combat skills are noted, though specific feats aren't detailed. A recurring source of humor stems from Kataoka's self-consciousness about her perceived lack of femininity, especially during activities like learning "slang conversation" from Irina Jelavić.

Her no-nonsense attitude is evident when, during a body-swapping incident caused by a cursed chest, she physically restrains Taiga Okajima to prevent him from misusing her body. In another event, she and most male classmates fail to enter the Elf Queen's realm due to a barrier blocking those with impure thoughts, highlighting the spin-off's playful take on her character.

The spin-off does not address Kataoka's background, academic struggles, relationships, or her aspiration to become a flight attendant. Her interactions with characters like Isogai, Kaede Kayano, and Hinata Okano are simplified for comedy. She primarily functions as part of ensemble gags, such as her inability to pass certain barriers alongside classmates deemed perverted. Within the spin-off's storyline, Kataoka participates in quests and battles but remains a supporting figure without significant character development or dedicated focus on her growth.