Misuzu Kamio, a 16-year-old girl with sky-blue eyes and long blonde hair often swept into a ponytail, radiates a blend of cheerful innocence and endearing clumsiness, frequently stumbling over invisible obstacles. Her childhood dinosaur obsession left an unusual mark: a habit of exclaiming "Gao" when flustered, a vocal quirk her adoptive mother, Haruko Kamio, persistently tries to curb. Cursed by her lineage as the reincarnation of Kannabi-no-Mikoto, Misuzu suffers a mysterious illness tied to emotional bonds. Forming connections triggers uncontrollable weeping and physical decline, baffling doctors who initially dismissed her symptoms as childhood ailments. Over time, her health deteriorates, regressing her behavior to a childlike state, erasing memories, and confining her to a wheelchair. Her life shifts upon meeting Yukito Kunisaki, a wandering puppeteer. Bonding with him and Haruko brings fleeting joy but accelerates her sickness. When her biological father attempts to reclaim her, she defiantly reaffirms Haruko as her true mother. In her final moments, yearning to reach the sea, she struggles to walk toward Haruko and Yukito, declaring them her "goal" before collapsing into Haruko’s arms, her death shattering the ancestral curse. Isolation defines her existence, as friendships risk her survival. Yukito’s companionship offers temporary solace while hastening her fate. Sunflowers and peach-flavored drinks symbolize her enduring optimism amid tragedy, her resilience contrasting her fragile body. In crossover appearances, her core traits persist—clumsiness, "Gao" exclamations, and tragic curse—without altering her arc. Her sacrifice breaks the cycle of her lineage’s suffering, intertwining redemption with inevitable loss.