Monkey D. Ruffy commands the Straw Hat Pirates, prioritizing his crew's safety and unity above all else. When Nico Robin departs with the government assassins CP9, Ruffy immediately leads his remaining crew to rescue her, determined to protect every member regardless of the cost.

A physical confrontation erupts between Ruffy and Usopp over the fate of the damaged ship, Going Merry. This clash stems from their differing views on the ship's seaworthiness, forcing Ruffy to bear the emotional weight of his captain's responsibilities. The crew, including Ruffy, cherishes the Going Merry not just as a vessel but as a beloved friend and irreplaceable member of their nakama.

Ruffy tackles complex situations with a straightforward, instinctual approach, often cutting through complications with decisive action. This manifests during the perilous Enies Lobby mission to retrieve Robin; his focus remains unwavering on reclaiming his crewmate despite overwhelming opposition. His resilience and optimism drive the crew forward during their challenging assault on Enies Lobby to rescue their captured comrade.