In *Dragon of Doom*, Fujiko collaborates with Lupin III and Jigen to recover a golden dragon statue lost aboard the Titanic, a treasure also pursued by the Hong Kong crime lord Chin Chin Chow. She infiltrates a masquerade ball on Chin Chin Chow's luxury cruise ship disguised as a cowgirl, demonstrating her mastery of disguise and infiltration. Ambushed mid-shower by the ninja Genzai, Fujiko is captured, revealing moments of vulnerability. She is subsequently held hostage by Chin Chin Chow.

During the special, Fujiko exhibits critical vulnerabilities when exposed to Chin Chin Chow's "hate plague" gas. This toxin induces uncontrollable aggression and laughter, affecting Fujiko alongside Jigen and Goemon until Lupin facilitates their escape. Her captivity and psychological manipulation during this sequence contrast with her typical role as an instigator of betrayal.

Her established skillset includes proficiency with firearms (favoring a Browning M1910 pistol holstered in her garter), martial arts capable of incapacitating larger opponents, multilingual fluency, and vehicular expertise. While not explicitly showcased in *Dragon of Doom*, these capabilities underpin her effectiveness as a thief.

Fujiko's relationship with Lupin III is complex and undefined, oscillating between partnership and rivalry without formal commitment. She leverages his affections for tactical advantage but avoids endangering him irreversibly. Occasional displays of concern for him surface during life-threatening scenarios, though she typically conceals such emotions post-crisis. Her aesthetic preferences favor fashionable attire that accentuates her physique.

Fujiko's background includes connections to organized crime, notably a past partnership with the assassin Killer Poon under a syndicate. This history involves memory loss covering years prior to meeting Lupin III. Her motivations consistently prioritize self-interest, aligning with her established persona as a self-reliant femme fatale.