Angelica Burns operates as a private investigator affiliated with the Federation Bureau, holding deep knowledge of systemic government corruption perpetrated by the Criminal Guild. Her professional focus centers on the relentless pursuit of the space pirate Mister, a chase spanning four years that originated during her earlier career as a traffic officer.

This pursuit carries underlying personal motivations, which evolve into romantic feelings toward Mister, becoming a driving force behind her efforts to apprehend him. Angelica demonstrates notable physical capabilities, facing off directly against formidable adversaries like the android assassins called the Twelve Sisters.

Distinct personality traits define her: she exhibits a notorious gluttony, paired with an apparently accelerated metabolic rate and speculation about potential hypoglycemia. Her partnership with police officer Chelsea forms after Chelsea uncovers institutional corruption and resigns her position to become Angelica's investigative partner.

Character development occurs through her interactions with the Coyote crew during the treasure hunt on Graceland. While maintaining her pursuit of Mister, her motivations gradually shift beyond professional duty. Mister assigns her the nicknames "Angel" and "Sexy," reflecting his perception of their complex dynamic.