"Coyote Ragtime Show" is a 12-episode anime series set in a futuristic universe where space travel and advanced technology are commonplace. The narrative centers on a group of spacefaring outlaws led by Mister, a charismatic and skilled criminal mastermind. Mister and his crew, including the android Bishop and the sharpshooter Katana, are on a mission to recover a legendary treasure hidden on the planet Graceland. This treasure, known as the "Chest of Demons," is said to contain immense wealth and power, making it a highly sought-after prize.

The story begins with Mister being released from prison, only to immediately resume his pursuit of the Chest of Demons. However, he is not the only one after the treasure. The Galactic Police Force, led by the determined Inspector Angelica Burns, is hot on his trail, aiming to bring him to justice. Additionally, a group of ruthless assassins known as the Twelve Sisters, who serve a powerful crime syndicate, are also vying for the treasure, adding layers of conflict and danger to the mission.

As Mister and his crew navigate through treacherous space battles, planetary obstacles, and confrontations with both the police and the Twelve Sisters, the stakes continue to rise. The planet Graceland itself is on the brink of destruction, set to explode in just 88 hours, adding a ticking clock element to the narrative. The series balances action-packed sequences with moments of character development, particularly focusing on Mister's resourcefulness and leadership, Bishop's loyalty and combat skills, and Katana's sharpshooting prowess.

The interplay between the main characters and their adversaries drives the plot forward, with alliances shifting and betrayals occurring as the race for the treasure intensifies. The series culminates in a high-stakes showdown on Graceland, where the true nature of the Chest of Demons is revealed, and the fates of the characters are decided. "Coyote Ragtime Show" combines elements of space opera, heist, and action genres, delivering a fast-paced and engaging story with a focus on adventure and camaraderie among its central characters.