Angelica, originally named Angelina, narrowly survived a staged hit-and-run orchestrated by her father to claim life insurance, emerging as the Social Welfare Agency’s first cyborg. Paired with handler Marco Toni, she was renamed Angelica—a nod to her perceived innocence, contrasting her brutal past. Cybernetic enhancements and memory-erasing conditioning stripped her former gregariousness, leaving her withdrawn and distant, straining her partnership with Marco.

As the inaugural test subject for memory conditioning, she suffered severe side effects: progressive, Alzheimer’s-like deterioration marked by fleeting recollections, even of recent events. Though critically injured during a Season 1 mission, she recovered and resumed duties, yet Section 2 questioned her stability. Her decline accelerated in the manga, eroding cognition and motor function irreversibly.

In *Il Teatrino*, Angelica redeployed prematurely, joining Marco, Jean, and Rico to infiltrate Milan-based terrorists, underscoring her tenuous operational value amid failing health. Her arc culminated in reconciling with Marco, where she recited his fabricated "Prince of Pasta" story—once a conditioning distraction—now hollow comfort as she no longer recognized him.

Exclusively wielding Steyr-Mannlicher firearms (AUG A2, TMP, M-A1 pistol, AUG H-BAR LMG), her armory mirrored Marco’s tactical ethos. Her eventual death marked the first cyborg fatality linked to conditioning’s long-term toll, framing the Agency’s ethically fraught experiments in visceral tragedy.