Natsume Amano is the daughter of Nathan "Nate" Adams (formerly Keita Amano) and Katie Forester (formerly Fumika Kodama), with a younger brother named Keisuke Amano (also known as Tate Adams in some media). Her lineage connects her to the legendary Yo-kai Watch user Nate, though she initially remains unaware of her father's history. A childhood near-drowning in a river, where she was mysteriously saved by an unknown figure, profoundly shaped her determination to help others and later ties into her discovery of a key-shaped charm revealed to be a Yo-kai Ark. At age 13 in *Yo-kai Watch Shadowside: Oni-ō no Fukkatsu*, Natsume becomes central when the Onimaro Yo-kai virus infects humans, transforming her mother and brother into Kaodeka Oni. Chosen by the Yo-kai Watch Elder (Yo-kai Watch Arcane), bestowed by Whisper, she gains the ability to summon Yo-kai using Keystones or Arks, activating their "Lightside" or "Shadowside" forms. Partnering with Jibanyan and allies like Akinori Arihoshi, she confronts the Oni King Rasen. Her pivotal actions include reconciling with Touma Tsukinami, a former antagonist corrupted by the Onimaro, and aiding in his redemption. Following these events, Natsume co-founds the Yo-kai Detective Agency with Touma and Akinori, solving supernatural cases while balancing school life. Her brother Keisuke occasionally assists despite his Yo-kai skepticism. Her relationships are multifaceted: a protective yet occasionally exasperated dynamic with Keisuke; a deep, history-bound friendship with Touma (known since elementary school); and a teasing but respectful rapport with Akinori. Natsume exhibits a strong sense of justice and selflessness, often prioritizing others' safety. Her personality mirrors her father's, including occasional irritability with overbearing Yo-kai like Micchy (Mitsumata Nozuchi). She later learns of her reincarnation as Juno, an ancient Oni Tribe princess, awakening transformative powers manifested through physical changes like red eyes, horns, and enhanced abilities to combat threats like Overseer. This connection draws loyalty from Oni Tribe members Shutendoji and Voidera. In *Yo-kai Watch 4*, Natsume is a playable character investigating Yo-kai incidents. She discovers her father's legacy as the "Legendary Yo-kai Watch User" and collaborates with him to resolve time-paradox crises threatening her existence, confronting malice-infested Yo-kai and aiding allies across different time periods. Physically, Natsume has dark brown eyes and hair, typically worn in braids resembling her paternal great-grandmother's style. Her standard attire is a high-school uniform: white shirt, pale yellow vest, blue blazer, pink bowtie, black skirt, knee socks, and brown shoes. Her name "Natsume" incorporates "natsu" (summer), reflecting the series' seasonal motifs.