Senku Ishigami displayed exceptional scientific intellect from childhood, conducting experiments and building devices like a miniature rocket. His adoptive father, Byakuya Ishigami, supported his pursuits, though Senku occasionally exploited this trust, such as using Byakuya's credit card for scientific purchases. He maintained friendships with Taiju Oki and Yuzuriha Ogawa, assisting their endeavors while remaining personally disinterested in romance. Before the global petrification event, he corresponded with scientist Dr. Xeno and pursued knowledge internationally, including studying Ebola in Africa. Petrified during the global event, Senku retained consciousness, meticulously counting seconds for approximately 3,700 years to track time. Revived in April 5738 AD, he analyzed nitric acid's role in his depetrification and formulated revival fluid using nital (nitric acid and ethanol). He revived Taiju and Yuzuriha, but their efforts were disrupted by Tsukasa Shishio, whom they revived to counter a lion attack. Tsukasa, opposing the revival of modern society, betrayed them, fatally injuring Senku. Senku survived due to residual petrification protecting his neck, and Taiju and Yuzuriha faked his death to escape. Senku later discovered Ishigami Village, founded by descendants of Byakuya's astronaut crew. He learned of his status as a village legend and became chief after winning the Grand Bout. He integrated villagers into his "Kingdom of Science," recognizing Kohaku as a warrior, Chrome as a scientifically-minded apprentice, and Kaseki as a master craftsman. He cured the priestess Ruri with antibiotics, solidifying trust. His leadership emphasized delegation based on individual strengths, utilizing allies like Gen Asagiri for diplomacy and Taiju for labor. The conflict with Tsukasa's Empire of Might escalated into the Stone Wars. Senku prioritized non-lethal strategies, developing technologies like the steam-powered "Steam Gorilla" tank, paper shields, and sonic weapons. He orchestrated psychological operations, broadcasting a recording of singer Lillian Weinberg via a crafted telephone to demoralize Tsukasa's forces. He successfully turned key members of Tsukasa's faction, including Ukyo Saionji and Nikki Hanada, to his side. After Tsukasa was critically wounded by Hyoga, Senku cryogenically preserved him for future healing via petrification technology. Following Tsukasa's defeat, his empire merged with the Kingdom of Science under the "Five Wise Commanders." Senku's personality centers on intense curiosity, logical reasoning, and confidence in science's power. He readily admits errors, such as overlooking Earth's axial precession when navigating by the North Star. Though often manipulative or secretive—like withholding calcium carbonate's use in gunpowder—his actions aim to benefit humanity. He exhibits a strong moral compass, refusing to abandon allies and showing deep, though rarely expressed, emotion regarding Byakuya's legacy. He dismisses romance as illogical but supports others' relationships. Despite physical frailty and average craftsmanship, his mental resilience, encyclopedic knowledge, and tactical ingenuity compensate. Post-Stone Wars, Senku led the Kingdom of Science in building the ship Perseus for global exploration. Discovering a message ("WHY") from the enigmatic "Why-Man," he sought its origin, suspecting extraterrestrial involvement. Traveling to Treasure Island (later the Petrification Kingdom), he confronted minister Ibara and warrior Kirisame, who wielded petrification devices. After most of his crew was petrified, Senku, with a small team including Kohaku and Gen, defeated Ibara, secured the petrification device ("Medusa"), and liberated the island. He planned to use petrification's healing properties to save Tsukasa and later collaborated with Dr. Xeno to reach Why-Man on the moon.