Akemi Ito is a human student at Myōjin University. In anime adaptations, she is initially portrayed as young, innocent, and naive. She becomes the girlfriend of Tatsuo Nagumo, the human destined to father the Chōjin—a supreme being prophesied to unite the three realms. This relationship positions Akemi as the future mother of the Chōjin, granting her a central role in the overarching prophecy.

The manga depicts her characterization differently, showing her as more sexually adventurous and occasionally obsessive about sexual matters. This contrasts with her anime counterpart, who maintains a compassionate and comparatively pure demeanor despite surrounding chaos. Her innocence in the anime serves as a narrative counterpoint to pervasive erotic and violent elements.

Akemi faces multiple threats, including a violent sexual assault by the demon-possessed teacher Togami. Nagumo and Amano Jyaku rescue her. As the Chōjin's mother, she possesses near invulnerability, protected by the Chōjin's power. This makes her untouchable by any force except the Kyō-Ō, the Chōjin's antithesis. Her protection is so absolute that suicide becomes impossible for her.

Throughout apocalyptic events—including the merging of the three worlds and Nagumo's transformation into the Demon of Destruction—Akemi retains her compassionate outlook. Her relationship with Nagumo is marked by tragedy, as he is fated to decimate the world to pave the way for their offspring's birth.

In the anime, Akemi's unwavering compassion and symbolic purity persist as the world descends into destruction and nihilism. Her role as the mother of the new deity underscores her narrative significance beyond mere victimhood.