"Teasing Master Takagi-san" is a slice-of-life manga centered around the daily interactions between two middle school students, Nishikata and Takagi. Nishikata is a boy who often finds himself the target of Takagi's playful teasing. Despite his efforts to outsmart her or turn the tables, Nishikata consistently falls short, as Takagi seems to anticipate his every move. Their relationship is built on a series of lighthearted challenges and games, ranging from riddles and wordplay to physical competitions, all of which Takagi dominates with ease.

The narrative unfolds in a episodic format, with each chapter presenting a new scenario where Nishikata attempts to outwit Takagi, only to be outmaneuvered by her cleverness and intuition. Takagi's teasing is never malicious; instead, it reflects her fondness for Nishikata and her enjoyment of their dynamic. Nishikata, while often frustrated, gradually becomes more aware of his growing feelings for Takagi, though he struggles to express them.

The manga explores themes of friendship, young love, and the innocence of adolescence. The interactions between the two characters are characterized by a blend of humor and subtle emotional depth, as their bond deepens over time. Supporting characters, such as their classmates Mina, Sanae, and Nakai, occasionally appear, adding variety to the story but remaining secondary to the central relationship between Nishikata and Takagi.

The setting is primarily their school and the surrounding neighborhood, emphasizing the simplicity and relatability of their experiences. The tone remains consistently light and comedic, with occasional moments of introspection that hint at the characters' evolving emotions. The series captures the essence of youthful camaraderie and the small, everyday moments that define growing up.