"Ao-chan Can't Study!" is a romantic comedy manga that centers on Ao Horie, a high school student determined to excel academically and gain admission to a prestigious university. Her focus on studies is constantly challenged by her overactive imagination and her father's influence. Ao's father, a bestselling erotic novelist, has inadvertently shaped her perception of romance and relationships, leading her to interpret even the most innocent interactions as suggestive or perverse. This internal struggle creates a humorous dynamic as Ao attempts to navigate her daily life while suppressing her intrusive thoughts.

The story gains momentum when Ao encounters Takumi Kijima, a popular and straightforward classmate who develops an interest in her. Kijima's earnest and uncomplicated approach to romance contrasts sharply with Ao's exaggerated and often comedic misinterpretations of his intentions. Their interactions are marked by misunderstandings, as Ao's overactive imagination leads her to believe Kijima's actions are driven by ulterior motives, while he remains genuinely sincere in his feelings. This tension drives much of the series' humor and character development.

Throughout the narrative, Ao's relationships with other characters, including her best friend Miyabi and her father, further complicate her attempts to maintain a normal high school life. Her father, while well-meaning, often embarrasses Ao with his public persona and his tendency to involve her in his work. Miyabi, on the other hand, provides a grounded perspective, offering support and occasionally teasing Ao about her struggles. The series balances comedic moments with heartfelt scenes, exploring themes of self-acceptance, the complexities of familial relationships, and the challenges of overcoming personal insecurities.

The manga's pacing and episodic structure allow for a mix of standalone comedic scenarios and ongoing character development. Ao's journey is one of gradual growth, as she learns to confront her anxieties and embrace her feelings for Kijima without letting her imagination derail her progress. The series concludes with a satisfying resolution to Ao's internal conflicts, as she begins to reconcile her academic ambitions with her personal life, ultimately finding a balance between her aspirations and her emotions.