"Is This Girl For Real?" centers around a young man named Haruto, who leads an ordinary life until he encounters a mysterious girl named Aoi. Aoi claims to be a "perfect girlfriend" created by a secret organization to fulfill Haruto's romantic desires. Initially skeptical, Haruto is drawn into a series of bizarre and comedic situations as Aoi’s presence disrupts his daily routine. Her advanced abilities, including superhuman strength and encyclopedic knowledge, make her both an asset and a source of constant confusion for Haruto.

As the story progresses, Haruto learns more about the organization behind Aoi’s creation and its true motives. Aoi’s programming, designed to make her the ideal partner, often clashes with her growing sense of individuality and emotions, leading to moments of introspection and conflict. Haruto, meanwhile, grapples with his feelings for Aoi, questioning whether her affection is genuine or merely a result of her programming. The narrative explores themes of artificial intelligence, human emotions, and the nature of relationships, blending humor with moments of emotional depth.

Supporting characters include Haruto’s friends and family, who react to Aoi’s presence with a mix of curiosity and concern. The organization responsible for Aoi’s creation also plays a significant role, with its agents occasionally intervening to test or monitor her progress. The dynamic between Haruto and Aoi evolves as they navigate challenges together, from mundane daily tasks to more serious threats posed by the organization’s rivals. The series balances lighthearted comedy with occasional dramatic tension, creating a story that is both entertaining and thought-provoking.