"Yamato Nadeshiko Zero Zero Seven" is a manga series that blends comedy, romance, and action, centering on the life of a high school girl named Kiri Koshiba. Kiri is a skilled martial artist and the heir to a prestigious ninja clan, the Koshiba family. Despite her extraordinary abilities, she struggles with her desire to live a normal life, free from the expectations and responsibilities tied to her lineage. Her family, however, has other plans, as they assign her a mission to protect a boy named Yuki Morisaki, who is the heir to a rival ninja clan.

Yuki is initially unaware of Kiri's true identity and her mission to guard him. He is a typical high school student, albeit with a kind and somewhat naive personality. As Kiri begins her undercover role as his classmate, she finds herself navigating the complexities of high school life while simultaneously fulfilling her duties as his protector. The dynamic between Kiri and Yuki evolves as they grow closer, with Kiri often torn between her feelings for Yuki and her obligations to her family.

The series incorporates elements of slapstick comedy, particularly through Kiri's exaggerated reactions and the absurd situations she finds herself in. Her ninja training often leads to over-the-top action sequences, which contrast humorously with the mundane setting of high school. The narrative also explores themes of duty versus personal desire, as Kiri grapples with the expectations placed upon her by her family and her own aspirations for a normal life.

Supporting characters include Kiri's family members, who frequently intervene in her mission, often complicating matters further. Yuki's interactions with Kiri and her family reveal his own struggles with identity and the legacy of his clan. The series balances its comedic and action-driven moments with quieter, more introspective scenes that delve into the characters' motivations and relationships.

As the story progresses, Kiri and Yuki face various challenges, including rival ninja clans, misunderstandings, and the pressures of their respective heritages. The manga maintains a lighthearted tone while occasionally delving into more serious themes, creating a narrative that is both entertaining and emotionally resonant. The interplay between Kiri's dual life as a ninja and a high school student drives much of the plot, culminating in a story that is as much about self-discovery as it is about action and romance.