"Shinsetsu Bobobo-bo Bo-bobo" is a surreal and comedic manga series that blends absurd humor, action, and parody. The story is set in a dystopian future where the tyrannical Emperor Tsuru Tsurulina IV and his organization, the Balding Empire, seek to eradicate all hair from the world. The protagonist, Bobobo-bo Bo-bobo, is a muscular, afro-haired warrior who possesses the unique ability to communicate with and manipulate his own body hair, using it as a weapon in battle. Alongside his eccentric companions, Bo-bobo embarks on a mission to thwart the Balding Empire's plans and protect the freedom of hair.

The narrative is episodic, with Bo-bobo and his allies encountering a series of bizarre adversaries, each with their own peculiar abilities and quirks. These battles often escalate into chaotic and nonsensical scenarios, with the series frequently breaking the fourth wall and parodying various genres, including shonen manga tropes. Key allies include Beauty, a young girl with a crush on Bo-bobo; Don Patch, a flamboyant and unpredictable fighter; and Gasser, a stoic and mysterious warrior. Each character contributes to the series' over-the-top humor and unpredictable tone.

Themes of individuality, resistance against oppression, and the celebration of absurdity are woven throughout the story. Despite its comedic focus, the series occasionally delves into moments of genuine emotion and character development, particularly in its exploration of Bo-bobo's past and his motivations for fighting the Balding Empire. The manga's humor is heavily reliant on slapstick, wordplay, and surrealism, making it a distinctive and polarizing entry in the comedy genre. The plot maintains a loose structure, prioritizing humor and creativity over a tightly woven narrative, resulting in a series that thrives on unpredictability and irreverence.