"Mobile Suit Crossbone Gundam: Ghost" is a manga series set in the Universal Century timeline, serving as a sequel to "Mobile Suit Crossbone Gundam." The story takes place in UC 0169, several decades after the events of the original "Crossbone Gundam." The narrative centers on the remnants of the Crossbone Vanguard, a group of space pirates, as they confront new threats to the Earth Sphere.

The protagonist, Kincaid Nau, is a young pilot who inherits the legacy of the Crossbone Vanguard. Kincaid operates the Gundam F99 Record Breaker, a next-generation mobile suit designed to combat the growing influence of the Jupiter Empire, a powerful faction seeking to dominate the Earth Sphere. The Jupiter Empire, led by the enigmatic Crux Dogatie, deploys advanced mobile suits and bio-engineered soldiers known as the "Ghosts," who possess enhanced physical and mental capabilities.

As the conflict escalates, Kincaid and his allies uncover the Jupiter Empire's plans to use a massive space fortress, the "Europa," to launch an invasion of Earth. The Crossbone Vanguard, though outnumbered and outgunned, relies on ingenuity and the unique capabilities of their mobile suits to counter the Empire's technological superiority. The story explores themes of resistance, legacy, and the moral complexities of warfare, as Kincaid grapples with his role in the ongoing struggle.

Key characters include Bernadette Briett, a skilled pilot and Kincaid's close ally, and Tobia Arronax, a veteran of the original Crossbone Vanguard who provides guidance and support. The series also introduces new antagonists, such as the Ghost pilots, who serve as formidable adversaries for Kincaid and his team. The narrative balances intense mobile suit battles with moments of character development, highlighting the personal stakes for those involved in the conflict.

"Mobile Suit Crossbone Gundam: Ghost" expands on the lore of the Universal Century, offering a continuation of the Crossbone Vanguard's story while introducing new challenges and adversaries. The series maintains a focus on the interplay between technological advancement and human resilience, set against the backdrop of a sprawling interstellar conflict.