"Nōgyō Musume!" centers on the life of Ichigo Aisuki, a high school girl who moves from the bustling city to the countryside to live with her grandmother after her parents relocate overseas. The narrative explores Ichigo's adjustment to rural life, highlighting the stark contrast between her urban upbringing and the agricultural lifestyle she must now embrace. Her grandmother, a seasoned farmer, introduces her to the intricacies of farming, from planting crops to caring for livestock, while also imparting lessons on self-sufficiency and the value of hard work.

The story delves into Ichigo's relationships with the local community, particularly her classmates at the small rural school she attends. Among them is Kousaku Hata, a boy deeply rooted in farming traditions, who becomes both a rival and a source of support as Ichigo navigates her new environment. The series also features other characters, such as Ichigo's childhood friend, who occasionally visits from the city, and various townspeople who contribute to her growth and understanding of rural life.

As Ichigo becomes more involved in farming, she faces numerous challenges, including unpredictable weather, crop failures, and the physical demands of agricultural work. These experiences are balanced with moments of camaraderie and humor, as she bonds with her peers and learns to appreciate the rhythms of nature. The narrative emphasizes themes of perseverance, community, and the rewards of connecting with the land, offering a grounded portrayal of rural life through Ichigo's evolving perspective.

The manga blends slice-of-life storytelling with educational elements, providing insights into farming techniques and the realities of agricultural work. Through Ichigo's journey, the series captures the struggles and triumphs of adapting to a new way of life, making it a relatable and informative exploration of rural culture and personal growth.