Hidden in the backstreets of Tokyo's upscale Ginza district is a small, nearly invisible bar called Eden Hall. Rumor claims that ordinary people cannot find it; instead, the bar must find them, inviting in only those who carry a heavy burden on their shoulders. Behind the counter stands Ryu Sasakura, a young bartending prodigy known as the "Glass of the Gods" for his legendary ability to mix the perfect cocktail for each troubled soul who walks through his door.

Unlike typical bartenders, Sasakura does more than pour drinks. He is a quiet listener and a subtle guide, using his vast knowledge of cocktail history, spirits, and mixing techniques to help his customers reflect on their lives. As he serves drinks ranging from a simple Highball to an obscure vintage liqueur, he helps a cast of desperate patrons ranging from heartbroken salarymen and weary lawyers to celebrated entertainers and stressed executives find the clarity they need to confront their problems. For Sasakura, tending bar is not merely a job but a calling; he believes a great cocktail can serve as a "Glass of the Gods" that revives the human spirit.

The central narrative framework involves the Hotel Cardinal, a major corporation seeking a new head bartender for its flagship bar. The hotel's president, Taizo Kurushima, becomes fascinated by Sasakura's philosophy and abilities. Kurushima's granddaughter, Miwa Kurushima, an office lady who initially visits Eden Hall to solve a mystery from her childhood involving a broken bottle of rare whiskey, becomes a regular presence at the bar and acts as a bridge between the solitary bartender and the outside world. She frequently tries to recruit Sasakura for the hotel, creating tension between his desire for the quiet independence of Eden Hall and the prestige of a high-profile position.

The episodic customer stories are interwoven with several notable narrative arcs. One arc focuses on the history of Eden Hall itself, exploring its origin and the legend of the "Luck of Edenhall" a cursed fairy cup that gives the bar its name and symbolizes the fragility of happiness. Another arc follows Sasakura's own past, revealing his rigorous training in France and the deep professional respect and rivalry he shares with other master bartenders in Tokyo. A significant story involves an aging bar owner and his reconciliation with a former business partner, reflecting the series' ongoing theme of using the ritual of drinking to heal old wounds and rebuild broken relationships. Ultimately, the manga follows Sasakura as he navigates the delicate balance between the intimate, almost sacred space of his small bar and the relentless pressures of the commercial world that seeks to claim his talent.