Following the Raccoon City Incident, former S.T.A.R.S. officers Chris Redfield and Jill Valentine now operate as part of a private anti-biohazard unit, working to track down and contain outbreaks linked to the Umbrella Corporation's viral weapons. Their investigation leads them to a remote village in the Russian Caucasus, where rumors spread of a wolf infected with the T-Virus that attacked the local inhabitants. Upon arrival, the two discover the settlement has been devastated: the residents have all been transformed into zombies. The only survivor is a young girl named Anna, who has witnessed the destruction of her home. As Chris and Jill fight through the infected villagers, the story exposes Umbrella's post-Raccoon City efforts to evade scrutiny, including the relocation of assets and the use of disinformation campaigns to maintain operational secrecy amid growing international attention. The manga serves as a prequel that leads directly into the events of the video game Resident Evil: The Umbrella Chronicles, detailing the early stages of the corporation's eventual collapse.