"Ōkami-san to Shichinin no Nakamatachi" is a manga series that blends comedy, action, and romance within a school setting. The story centers around Ryōko Ōkami, a strong and assertive high school girl who is part of the Otogi High School's "Otogi Bank," a student-run organization that assists fellow students with their problems in exchange for future favors. Ryōko is known for her combat skills and no-nonsense attitude, often relying on her physical strength to resolve conflicts. Her partner, Ryōshi Morino, is a timid and socially anxious boy who harbors feelings for Ryōko but struggles to express them. Despite his shyness, Ryōshi is a skilled archer and provides crucial support to Ryōko during their missions.

The Otogi Bank is composed of seven members, each with unique abilities and personalities. The group takes on various requests from students, ranging from dealing with bullies to solving personal disputes. As the series progresses, the dynamics between the members are explored, particularly the evolving relationship between Ryōko and Ryōshi. Ryōko's tough exterior gradually softens as she begins to acknowledge Ryōshi's feelings, though her pride often complicates their interactions. The narrative also delves into the backstories of the other members, revealing their motivations and personal struggles.

The series incorporates elements of fairy tales and folklore, with many characters and situations drawing inspiration from classic stories. This thematic layer adds depth to the narrative, as the characters often find themselves in scenarios that parallel well-known tales, albeit with a modern twist. The blend of humor, action, and heartfelt moments creates a balanced tone, appealing to readers who enjoy lighthearted yet emotionally engaging stories.

Throughout the manga, the Otogi Bank faces various challenges that test their teamwork and individual resolve. The missions they undertake often lead to personal growth for the characters, particularly Ryōko and Ryōshi, as they navigate their feelings and confront their insecurities. The series concludes with a focus on the bonds formed within the group, emphasizing the importance of friendship and mutual support in overcoming life's obstacles.