"Ookami-san to Shichinin no Nakama-tachi" is a 12-episode anime series that blends comedy, romance, and action within a high school setting. The story centers around Ryoko Ookami, a strong-willed and physically adept girl who is a member of the Otogi High School's "Otogi Bank," a club that assists students with their problems in exchange for favors. Despite her tough exterior, Ryoko harbors insecurities about her femininity and struggles with expressing her emotions. Her partner, Ryoshi Morino, is a timid boy with a crush on Ryoko, who uses his sharpshooting skills to support her during missions. The dynamic between Ryoko and Ryoshi forms the core of the narrative, with Ryoshi's unwavering loyalty and affection gradually breaking through Ryoko's defenses.

The Otogi Bank is led by Ringo Akai, a cunning and manipulative strategist who orchestrates the club's operations. Other members include Otsuu Tsurugaya, a cheerful and energetic girl with superhuman strength; Alice Shirosaki, a quiet and mysterious hacker; and Liszt Lizarian, a flamboyant and narcissistic inventor. Together, they tackle various requests from students, ranging from retrieving stolen items to confronting bullies. Each mission reveals more about the characters' personalities and backstories, adding depth to their interactions and relationships.

The series incorporates fairy tale motifs, with characters often referencing or embodying traits from classic stories. Ryoko, for instance, is likened to the "Wolf" from "Little Red Riding Hood," while Ryoshi is compared to the "Hunter." These parallels are woven into the narrative, emphasizing themes of courage, trust, and self-discovery. The anime balances lighthearted humor with moments of tension and drama, particularly as Ryoko and Ryoshi's relationship evolves and the group faces increasingly challenging tasks.

The overarching plot is episodic, with most episodes focusing on a specific mission or character development. However, a recurring antagonist, Tarou Urashima, serves as a foil to the Otogi Bank, often complicating their efforts. His schemes and rivalry with the group add a layer of conflict that ties the individual episodes together. The series concludes with a resolution that underscores the growth of the characters and the bonds they have formed, leaving room for further exploration of their adventures.