"4-Nin wa Sorezore Uso o Tsuku" centers around four high school students—Yotsuya Yuu, Yokozeki Haru, Mukai Tooru, and Tachibana Mina—who form a unique bond through their shared habit of lying. Each character has a distinct reason for their dishonesty, and their lies often intertwine, creating complex and humorous situations. Yotsuya, the protagonist, lies to avoid social interactions and maintain a facade of indifference, while Yokozeki fabricates stories to appear more interesting. Mukai uses lies to manipulate others for personal gain, and Tachibana deceives to protect her self-image and avoid vulnerability.

The narrative unfolds as the four characters navigate their daily lives, often finding themselves entangled in each other's fabricated stories. Their lies range from trivial exaggerations to elaborate schemes, leading to misunderstandings, conflicts, and occasional moments of genuine connection. The series explores themes of trust, identity, and the consequences of deception, as the characters gradually confront the reasons behind their dishonesty and the impact it has on their relationships.

As the story progresses, the dynamics between the four characters evolve, with moments of camaraderie and tension. Their interactions reveal deeper layers of their personalities, challenging their initial perceptions of one another. The manga balances humor with introspection, presenting a blend of comedic scenarios and poignant reflections on human behavior. Through its exploration of lies and their repercussions, "4-Nin wa Sorezore Uso o Tsuku" offers a nuanced portrayal of adolescence and the complexities of interpersonal relationships.