"Burn the Witch" is set in Reverse London, a hidden mirror version of the city where dragons, invisible to ordinary humans, coexist with society. These dragons are managed by Wing Bind, an organization tasked with protecting and regulating them. The story centers on Noel Niihashi and Ninny Spangcole, two witches who work as agents for Wing Bind. Noel is calm and methodical, while Ninny is more impulsive and brash, creating a dynamic partnership as they handle dragon-related incidents.

The narrative begins with the introduction of Balgo Parks, a seemingly ordinary boy who becomes a target after accidentally forming a contract with a powerful dragon. This event draws the attention of Dark Dragons, malevolent entities that pose a significant threat. Noel and Ninny are assigned to protect Balgo, leading to a series of confrontations with dangerous dragons and uncovering deeper mysteries about Reverse London and its inhabitants.

As the story progresses, the witches face challenges that test their abilities and reveal hidden truths about their world. The plot explores the hierarchy and politics within Wing Bind, as well as the origins and nature of dragons. Themes of duty, loyalty, and the consequences of wielding power are woven into the narrative, with the characters navigating complex relationships and moral dilemmas.

The manga blends action, fantasy, and humor, with a focus on the interplay between its protagonists and the unique setting of Reverse London. The world-building introduces a variety of dragon species, each with distinct traits and roles in the ecosystem, while the characters’ growth and interactions drive the story forward. "Burn the Witch" offers a concise yet engaging exploration of its magical world, balancing episodic adventures with an overarching plot.